The United States presently spends more than $30 billion per year in public research through the National Institutes of Health (second only to the Department of Defense), and the private sector spends at least 50 percent more than that. Nevertheless, relatively little is known about long-run trends in these overall spending patterns, and the changing structure of who performs what research, where, and when. Even less is known about the international landscape of health R&D spending. InSTePP is working to fill this knowledge gap. New R&D spending estimates and evidence will be posted to this site, as they become available.